ReddIt. Sounds worth checking out. What side effects did you experience from Neurontin? Given the literature value, dosing according to Cutler Therapy would result in fluctuating between just over 100% and 1% blood levels, obviously suboptimal (and also below the clinical determination for elimination). garlic [42]) and brassicas (e.g., broccoli [43]) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. Results from certain studies demonstrate that long-term use of alphalipoic acid has beneficial effects on the development of retinopathy since it halts oxidative damage that can result in modified DNA in the retina. Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. Alpha-lipoic acid is a natural protective antioxidant. Recently, an oral controlled‐release formulation of alpha‐lipoic acid (CRLA) was developed, and a pharmacokinetic study demonstrated that CRLA maintained significant plasma levels for 67% longer than a common quick‐release formulation. Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. Lipoic acid also prevents diabetic neuropathy characterized by pain, burning, and stabbing sensations in the extremities. (iii) Given that toxic metals have a great affinity for sulfur-containing peptides, diets rich in sulfur-containing foods, such as alliums (e.g. I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid Common Name(s): Acetate replacing factor, Alpha-lipoic acid, Biletan, Lipoic acid, Lipoicin, Thioctacid, Thioctan, Thioctic acid reddit. Jarrow Formulas R-Alpha Lipoic Acid, Supports Energy, Cardio Vascular Health, 100 mg, 60 Caps. But lipoic acid declines in your body as you age. Some call it the “universal antioxidant” . Even if ALA can chelate mercury, it's not a compound that sounds likely to get eliminated afterwards. 5) Acetyl L-Carnitine and Alpha Lipoic Acid Price. But, there are few studies that refer to protective effects and potential mechanisms on traumatic brain injury (TBI). R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. Some make it worse. for evidence-based support, only the Cutler Therapy comes up. In animals, it decreased lead absorption into bone, and inhibited the action of the delta-aminolevulinic acid dehydratase (ALAD) enzyme [47]. Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. Effect of Alpha-Lipoic Acid Supplementation on Oxidative Stress Markers and Antioxidative Defense … Anyone with personal experiences either with fixing mercury toxicity in general or using Cutler Therapy care to explain this discrepancy? I haaven't found a thc prodcut that helps, yet. It’s made inside the mitochondrion — also known as the powerhouse of cells — where it … The selenide ion forms an extremely stable, insoluble compound with mercury, and provides relief of mercurialism symptoms. * A year ago my mother started suffering from some pretty obvious, and worrying memory loss. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. (iv) Cilantro (leaves of Coriandrum sativum), a popular culinary and medicinal herb, gained attention when a soup was reported to enhance mercury excretion following dental amalgam removal, and its use as a chelator remains popular despite limited evidence [46]. R-lipoic acid is the biologically active form of the key ‘mitochondrial antioxidant,’ alpha lipoic acid. Lipoic acid (LA), also known as alpha-lipoic acid (ALA), R-lipoic acid, or thioctic acid, is a disulfide-containing compound , found inside every cell of the body . Has anyone else tried this for neuropathy? Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies [39]. Press J to jump to the feed. This is a substantial difference. Good luck! Has anyone else tried this for neuropathy? Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. A friend was telling me about the antioxidant Alpha Lipoic Acid (ALA), and talking about how it can have anti-inflammatory effects. Due to its potential antioxidant activity, … Glutathione is an important physiological chelator, and the reduced form of glutathione protects cells from reactive oxygen species (ROS) associated with heavy metals [58, 59, 60, 61]. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations, and is a biomarker for toxic metal overload [29, 30, 31]. A selenium yeast product increased mercury excretion and decreased oxidative stress-related biomarkers, particularly urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine [63]. Because it protects the endothelium, alpha lipoic acid reduces the risk of diabetic vascular disease and kidney disease. Therefore, ALA supplements are preferably taken on an empty stomach to benefit of the acidic stomach pH. It serves vital functions at the cellular level, such as energy production. : (i) Taurine [49, 50, 51] and methionine [52] are sulfur-containing amino acids. She did, and within a few months her memory problems vanished completely. On the face of it, selenide might not be compatible with chelation, as the two agents may counter the effectiveness of one another [62]; however, selenium may be incorporated in organic molecules, and organic selenium/mercury complexes may be transported through membranes. You get small amounts of lipoic acid in your diet from spinach and collard greens, broccoli, beef and organ meats. Alpha‐lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. I'm intrigued by Lipoic Acid as a potential chelator for mercury , as I suffer from chronic mercury toxicity. ALA is also beneficial in combating damages and infections that attack vital organs. This is a unique & common antioxidant available in … Some foods have been suggested to reduce absorption or reabsorption of toxic metals and to support natural detoxification pathways. Tried on and off twice. New comments cannot be posted and votes cannot be cast. "ALA should be admitted at least 2 hr after eating or if taken before; meal should be taken at least 30 min after ALA administration In addition, it has been suggested that acidic pH of the stomach is favorable for ALA absorption through the gastrum. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. Yes. It is widely understood that alpha lipoic acid is manufactured endogenously within the human body and that its presence is essential for aerobic metabolism, or the means by which the body generates energy via breakdown of carbohydrates, amino … Being both fat and water-soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers [22, 53]. Alpha lipoic acid (ALA) is a naturally-occurring antioxidant within the body, but you can obtain incorporate it in your daily diet in the form of supplements. The price of this product is moderate and can even be considered cheap in comparison with similar products. 99. In humans, organic selenium supplementation was beneficial in a controlled trial among 103 mercury-exposed villagers [63]. https://www.amazon.com/R-Alpha-Lipoic-R-LIPOIC-count-STRENGTH/dp/B01M0QS5C7, There are many studies on its effectiveness available on the pubmed site. Yes, I've had that exact thing from a. lipoic acid too. In accordance with the serotonin theory of depression, it may be possible to treat depression by increasing insulin activity. Lipoic acid is unique among other antioxidants because it is both water- and fat-soluble. A subreddit for those living with neuropathy. Alpha lipoic acid has been used successfully to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease. When looking up information about this to gather case studies/evidence/etc. Alpha lipoic acid (ALA), also known as thioctic acid, is an eight-carbon organosulfur compound derived from caprylic acid (octenoic acid). R-lipoic acid is directly involved in cellular metabolism and is a vital component of the intracellular antioxidant cycle, able to scavenge a variety of free radicals and reactive oxygen species (ROS) while recycling vitamins C, E and glutathione. I'm intrigued by Lipoic Acid as a potential chelator for mercury, as I suffer from chronic mercury toxicity. It may be administered intravenously, in creams, and via nebulizer. Why do you think you have mercury toxicity? Optim-ALA Optimized Alpha Lipoic Acid should provide and support optimal mitochondrial function, energy … Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. (i) Dietary fibers from various food products, including bran from grains, as well as fruit, have been evaluated as an alternative or adjunct to chelation therapy, with the aim to interrupt enterohepatic recirculation [34, 35, 36], and to modulate intestinal flora [37], with findings of reduced levels of mercury in the brain and blood. Much higher doses for way longer periods of time and saw no change. Trying to keep its serum levels elevated is a failed proposition, and in fact it doesn't even free-float, rather, it's bound to lipoproteins. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… Optim-ALA Optimized Alpha Lipoic Acid utilizes two of the best, most bioavailable forms of R-ALA paired with sesame extract. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. They are rich in membranes, particularly of excitable tissues, and they decrease oxidative stress markers resulting from heavy metal exposure. Insights on the Use of α-Lipoic Acid for Therapeutic Purposeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318Here is a recent paper explaining what the researchers have tried using it for.Edit to add this quote from above paper. A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. As long as you're healthy, the body can produce all the ALA it needs for these purposes. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. CDN$ 5.54 shipping. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging [57]. Several supplements are also in use to address metal toxicities. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. Chelation is central to the natural detoxification of heavy metals, via the formation of complexes, particularly with glutathione and other small molecules, and their excretion [20]. * It has important characteristics that contribute to liver, nerve, and eye health. Despite that fact, there has been a lot of recent interest in using ALA supplements. I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. (ii) Alpha-lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. (ii) Other natural polymers have also been gaining attention as potential adsorbents of heavy metals, such as algal polysaccharides alginate [39] and chlorella [40]. Alpha-lipoic acid is an antioxidant that's in many foods, and it's made naturally in our bodies. Nonetheless, people claim moderate success using his regimen. (iii) N-acetyl-cysteine (NAC), an orally available precursor of cysteine, is a chelator of toxic elements and may stimulate glutathione synthesis, particularly in the presence of vitamins C and E [54, 55, 56]. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. After some research, I suggested she try taking the maximum recommended dose of alpha lipoic acid, which is an antioxidant that affects the brain. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. 300 mg of lipoic acid (of the R form of lipoic acid – see below for more detail) is recommended a day for diabetes management. If you have confirmed that you have mercury toxicity, get a real chelating agent, preferably one actually backed by clinical evidence, and don't try an unproven treatment that doesn't sound likely to work and could be harmful. Metal-binding proteins, including metallothioneins, are potent chelators for heavy metals and are central to the natural response of the body to these toxic elements [27, 28]. "This may explain why the results of trials are confusing.I'm going to have to change when I take mine. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … The dosage of lyrica prescribed is not giving good results. ALA has been widely explored as a beneficial nutrient for a variety of bodily functions involving the nervous, cardiovascular, immune and detoxification systems. Alpha-Lipoic Acid.
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